Name of the Natriuetics Anti Diuretic Drugs
Amiloride
| Amiloride |
| Availability Tablet 5mg |
| Indications and dosages Congestive Heart Failure 5-10 mg/day PO qDay OR divided q12hr Hypertension 5-10 mg/day PO qDay OR divided q12hr Thiazide-Induced Hypokalemia 5-10 mg/day PO qDay OR divided q12hr Renal Impairment CrCl 10-50 mL/minute: 50% normal dose CrCl <10 mL/minute: Not recommended |
Mechanism of Action
Exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. This mechanism accounts in large part for the potassium sparing action of amiloride.
Inhibits Na/K-ATPase, decreases Ca++, Mg++ and hydrogen excretion
Pharmacokinetics
- Half-Life: 6-9 hr
- Duration: 24 hr
- Onset: initial effect: 2-3 hr, max effect: 6-10 hr
- Peak Plasma Time: 3-4 hr
- Bioavailability: 30-90%
- Protein Bound: 23%
- Vd: 350-380 L
- Metabolism: NOT metabolized in the liver; no active metabolites
- Excretion Urine: 50% ,Feces: 40-50%
Contraindications
- Hypersensitivity to amiloride
- Hyperkalemia (K+ >5.5 mEq/L [5.5 mmol/L])
- Concomitant use with K+-sparing diuretic, or K supplementation
- Impaired renal function (Scr >1.5 mg/dL [132.6 umol/L], or BUN >30 mg/dL [10.7 mmol/L]) diabetes
Side –effects
- Feeling sick
- Skin rashes
- Dry mouth
REFERENCES
- Robert Kizior, Keith Hodgson, Saunders Nursing Drug handbook,1st edition 2024, Elsevier Publications. ISBN-9780443116070
- McGraw Hill- Drug Handbook, Seventh Edition, 2013, McGraw Hill Education Publications,9780071799430.
- April Hazard, Cynthia Sanoski, Davi’s Drug Guide for Nurses -Sixteenth Edition 2019, FA Davis Company Publications,9780803669451.
- Jones and Bartlet, Pharmacology for Nurses, Second Edition, 2020, Jones and Bartlet Learning Publications, ISBN 9781284141986.
- Nursebro.com, Search – Nursebro
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