Introduction
A needlestick injury occurs when a needle or other sharp object accidentally punctures the skin, potentially exposing the individual to blood-borne pathogens such as HIV, hepatitis B (HBV), and hepatitis C (HCV). It’s a significant occupational hazard, especially for healthcare workers, lab technicians, and sanitation staff

Definition
A needlestick injury is a percutaneous piercing wound from a needle point, sharp instrument, or object.
Protocol for Needlestick or Sharp Injury
- Do not panic and do not ignore the exposure.
- Do not put the pricked finger in the mouth or squeeze.
- Do not use bleach, chlorine, alcohol, (povidone-iodine) or any antiseptic or detergent.
- Wash the site with soap and water immediately.
- The exposure should be assessed (type of fluid, type of needle, amount of blood on the needle, reviewing the patient’s record for serology, immunosuppressive condition, etc.).
- Report the incident to the head nurse or to the HICC department and to the medical officer.
- An Exposure Report Sheet should be completed.
- The exposure source should be evaluated, where the information pertaining to the patient must be mentioned:
- Status of the patient.
- Consent and testing of the patient for these diseases if the status is unknown.
- Evaluation of the exposed person’s status for HIV, HCV, and HBV antibodies.
- Start post-exposure prophylaxis (PEP) as soon as possible.
- Re-evaluate the exposed individual within 72 hours.
- Check the status of the source.
HIV
- If the source is determined to be HIV negative, PEP (ART drug regimen) can be discontinued.
- If the source is determined to be HIV positive, continue treatment for 4 weeks if tolerated.
- The exposed person should undergo HIV antibody testing at 0, 6, 12, and 24 weeks irrespective of the status of the index patient. If the test at 6 months is negative, no further testing is recommended.
HBV
- If the source is determined to be HBV negative, PEP can be discontinued.
- If antibodies present are more than 100 IU/L, no PEP is required.
- If antibodies are nil, a booster dose of hepatitis B immunoglobulin + HBV vaccine booster dose is given.
HCV
- If the source is determined to be negative, stop PEP.
- If the source is anti-HCV antibody positive, HCV core Ag (HCV Ag) and HCV RNA is detected (presence of HCV Ag and HCV RNA indicates a high viral load and the patient has HCV infection), start pegylated interferon plus ribavirin therapy.
- Re-evaluate the exposed person after 1 month, and then after 3 months.
- If the exposed person’s HBV and HCV are negative, document in the Hospital Health Record.
Key Prevention Strategies
- Use Safety-Engineered Devices
- Utilize needleless systems and retractable needles to minimize exposure.
- Ensure proper training on safe device usage.
- Proper Handling & Disposal
- Never recap needles—use designated sharps containers.
- Dispose of sharps immediately after use in puncture-resistant containers.
- Follow Safe Work Practices
- Plan procedures to minimize handling of sharps.
- Avoid rushing and maintain awareness of surroundings.
- Wear Personal Protective Equipment (PPE)
- Use gloves, face shields, and gowns when handling sharps.
- Ensure PPE is readily available in all clinical areas.
- Undergo Proper Training
- Regular education sessions on sharps safety.
- Encourage reporting of near misses to improve protocols.
- Report & Address Needlestick Hazards
- Establish a bloodborne pathogen control program.
- Investigate all sharps-related injuries to prevent recurrence.
- Get Vaccinated
- Ensure hepatitis B vaccination for all healthcare workers.
- Follow post-exposure prophylaxis (PEP) protocols if needed.
- Follow Post-Exposure Protocols
- Wash needlestick injuries immediately with soap and water.
- Flush splashes to the nose, mouth, or skin with water.
- Irrigate eyes with sterile solutions.
- Report the incident and seek medical evaluation promptly.
REFERENCES
- Annamma Jacob, Rekha, Jhadav Sonali Tarachand: Clinical Nursing Procedures: The Art of Nursing Practice, 5th Edition, March 2023, Jaypee Publishers, ISBN-13: 978-9356961845 ISBN-10: 9356961840
- Omayalachi CON, Manual of Nursing Procedures and Practice, Vol 1, 3 Edition 2023, Published by Wolters Kluwer’s, ISBN: 978-9393553294
- Sandra Nettina, Lippincott Manual of Nursing Practice, 11th Edition, January 2019, Published by Wolters Kluwers, ISBN-13:978-9388313285
- Adrianne Dill Linton, Medical-Surgical Nursing, 8th Edition, 2023, Elsevier Publications, ISBN: 978-0323826716
- Donna Ignatavicius, Medical-Surgical Nursing: Concepts for Clinical Judgment and Collaborative Care, 11th Edition ,2024, Elsevier Publications, ISBN: 978-0323878265
- Lewis’s Medical-Surgical Nursing, 12th Edition,2024, Elsevier Publications, ISBN: 978-0323789615
- AACN Essentials of Critical Care Nursing, 5th Ed. Sarah. Delgado, 2023, Published by American Association of Critical-Care Nurses ISBN: 978-1264269884
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